Nebulizer therapy in cystic fibrosis: An overview
نویسندگان
چکیده
منابع مشابه
Gene therapy in cystic fibrosis.
Theoretically, cystic fibrosis transmembrane conductance regulator (CFTR) gene replacement during the neonatal period can decrease morbidity and mortality from cystic fibrosis (CF). In vivo gene transfers have been accomplished in CF patients. Choice of vector, mode of delivery to airways, translocation of genetic information, and sufficient expression level of the normalized CFTR gene are issu...
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An aerosol is defined as a suspension of liquid or solid particles in air or oxygen, and the process of forming an aerosol is called nebulization. Therapeutically an aerosol may be inhaled and may, but does not necessarily, contain mucolytic, therapeutic, or antibiotic agents. Common usage of aerosol in medicine usually means intermittent inhalation by face mask or oral tube. Mist tents are aer...
متن کاملAn empirical method to cluster objective nebulizer adherence data among adults with cystic fibrosis
BACKGROUND The purpose of using preventative inhaled treatments in cystic fibrosis is to improve health outcomes. Therefore, understanding the relationship between adherence to treatment and health outcome is crucial. Temporal variability, as well as absolute magnitude of adherence affects health outcomes, and there is likely to be a threshold effect in the relationship between adherence and ou...
متن کاملliver disease in cystic fibrosis: an update
context cystic fibrosis (cf) is the most widespread autosomal recessive genetic disorder that limits life expectation amongst the caucasian population. as the median survival has increased related to early multidisciplinary intervention, other manifestations of cf have emergedespecially for the broad spectrum of hepatobiliary involvement. the present study reviews the existing literature on liv...
متن کاملBarriers and recent advances in non-viral vectors targeting the lungs for cystic fibrosis gene therapy
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in CFTR genes that affect chloride ion channel. The CF is a good nominee for gene therapy as the asymptomatic carriers are phenotypically normal, and the desired cells are accessible for vector delivery. Gene therapy shows promising effects involving the correction of gene or replacement of the mutant gene with the func...
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 2009
ISSN: 0141-0768,1758-1095
DOI: 10.1258/jrsm.2009.s19003